Registry · media · Various
Hyaluronidase (denudation enzyme) — general
Enzyme used to loosen cumulus cells from oocytes before ICSI or maturity assessment.
What it is and how it's used
Whatever the brand, the failure modes are the same: exposure and concentration.
Typical failure modes
- Over-exposure → oolemma damage, degeneration, lower fertilisation.
- Under-exposure → residual cumulus, difficult ICSI, mechanical damage during stripping.
What to check first
- Seconds of exposure per oocyte batch.
- Dilution correctness.
- Lot/expiry.
IFU and practice notes
Follow the specific product IFU.
Neutral, and the IFU wins
This page summarises common experience across labs and is not manufacturer guidance. Always follow the current instructions for use for the exact product and version you have, and validate any change of product or protocol before patient use. Corrections and additions are welcome — tell us.
Shared with you by your clinic · Source: https://embryologics.com/embryologists/registry/hyaluronidase-general · Medical Interventions. Reviewed by a certified clinical embryologist. Educational information — please discuss your own situation with your clinic.
This page is educational and general. It is not a substitute for advice from your own clinic or the manufacturer's instructions for use.